Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박혜영 | - |
dc.date.accessioned | 2016-08-28T11:08:28Z | - |
dc.date.available | 2016-08-28T11:08:28Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1387-2273 | - |
dc.identifier.other | OAK-481 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218667 | - |
dc.description.abstract | Enantiomers may confer benefits over racemates in therapeutic uses and we developed a chiral separation method of cetirizine enantiomers, a second generation H1 histamine receptor antagonist, in rat plasma. α1-Acidglycoprotein based chiral stationary phase(AGP-CSP), monitored with UV at 230 nm was used to separate the enantiomers. Observed enantioselectivity (α) was 2.0. The AGP-CSP was also used at a preparative scale to isolate the enantiomers with an optical purity of greater than ee 99%. In addition, an analysis was carried out for the cetirizine enantiomers in rat plasma to study the differences of enantiomers in pharmacokinetics. Both (+)- and (-)-cetirizine were separated using a reversed-phase column of AGP, and were detected at the range of 2.5-200 μgml-1 in plasma. Although there was no recognizable differences in pharmacokinetics between the enantiomers in rat, the method appears to be useful for their pharmacokinetic studies. Copyright (C) 2000 Elsevier Science B.V. | - |
dc.language | English | - |
dc.title | Stereoselective determination of cetirizine and studies on pharmacokinetics in rat plasma | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 744 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 201 | - |
dc.relation.lastpage | 206 | - |
dc.relation.journaltitle | Journal of Chromatography B: Biomedical Sciences and Applications | - |
dc.identifier.doi | 10.1016/S0378-4347(00)00229-2 | - |
dc.identifier.wosid | WOS:000088680300024 | - |
dc.identifier.scopusid | 2-s2.0-0034617389 | - |
dc.author.google | Choi S.O. | - |
dc.author.google | Lee S.H. | - |
dc.author.google | Kong H.S. | - |
dc.author.google | Kim E.J. | - |
dc.author.google | Choo H.-Y.P. | - |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | - |
dc.date.modifydate | 20230411110509 | - |