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Cytotoxic effects of pyridino[2,3-f]indole-4,9-diones on human tumor cell lines

Title
Cytotoxic effects of pyridino[2,3-f]indole-4,9-diones on human tumor cell lines
Authors
Suh M.E.Park H.-K.Yoo H.-W.Lee C.O.
Ewha Authors
서명은
SCOPUS Author ID
서명은scopus
Issue Date
2000
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
0918-6158JCR Link
Citation
vol. 23, no. 3, pp. 354 - 355
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The cytotoxicities of pyridino[2,3-f]indole-4,9-dione derivatives were examined against human lung tumor cell lines (A 549), human ovarian tumor cell lines (SK-OV-3), human melanoma tumor cell lines (SK-MEL-2), human CNS tumor cell lines (XF 498) and human colon tumor cell lines (HCT 15) in vitro using a Sulforhodamine B assay. 3-Ethoxycarbonyl-1-(2-methoxyethyl)-2-methyl- 1H-pyridino[2,3-f]indole-4,9-dione (5) showed excellent cytotoxicity against XF 498 and HCT 15. The ED 50 values of 5 were 0.006 μg/ml against XF 498 and 0.073 μg/ml against HCT 15, while those of doxorubicin were 0.012 and 0.264 μg/ml, respectively. 1-Benzyl-3-ethoxycarbonyl-2-methyl-1H- pyridino[2,3-f]indole-4,9-dione (7) (ED 50 value 0.065 μg/ml) was also significantly more cytotoxic against HCT 15 compared with doxorubicin.
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