Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서명은 | * |
dc.date.accessioned | 2016-08-28T11:08:24Z | - |
dc.date.available | 2016-08-28T11:08:24Z | - |
dc.date.issued | 2000 | * |
dc.identifier.issn | 0918-6158 | * |
dc.identifier.other | OAK-388 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218618 | - |
dc.description.abstract | The cytotoxicities of pyridino[2,3-f]indole-4,9-dione derivatives were examined against human lung tumor cell lines (A 549), human ovarian tumor cell lines (SK-OV-3), human melanoma tumor cell lines (SK-MEL-2), human CNS tumor cell lines (XF 498) and human colon tumor cell lines (HCT 15) in vitro using a Sulforhodamine B assay. 3-Ethoxycarbonyl-1-(2-methoxyethyl)-2-methyl- 1H-pyridino[2,3-f]indole-4,9-dione (5) showed excellent cytotoxicity against XF 498 and HCT 15. The ED 50 values of 5 were 0.006 μg/ml against XF 498 and 0.073 μg/ml against HCT 15, while those of doxorubicin were 0.012 and 0.264 μg/ml, respectively. 1-Benzyl-3-ethoxycarbonyl-2-methyl-1H- pyridino[2,3-f]indole-4,9-dione (7) (ED 50 value 0.065 μg/ml) was also significantly more cytotoxic against HCT 15 compared with doxorubicin. | * |
dc.language | English | * |
dc.title | Cytotoxic effects of pyridino[2,3-f]indole-4,9-diones on human tumor cell lines | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 354 | * |
dc.relation.lastpage | 355 | * |
dc.relation.journaltitle | Biological and Pharmaceutical Bulletin | * |
dc.identifier.wosid | WOS:000085696900018 | * |
dc.identifier.scopusid | 2-s2.0-0342368809 | * |
dc.author.google | Suh M.E. | * |
dc.author.google | Park H.-K. | * |
dc.author.google | Yoo H.-W. | * |
dc.author.google | Lee C.O. | * |
dc.contributor.scopusid | 서명은(7103253844) | * |
dc.date.modifydate | 20240423081003 | * |