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Pharmacokinetic changes of cyclosporine after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure

Title
Pharmacokinetic changes of cyclosporine after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure
Authors
Lee Y.H.Park K.H.Ku Y.S.
Ewha Authors
구영순
SCOPUS Author ID
구영순scopusscopus
Issue Date
2000
Journal Title
International Journal of Pharmaceutics
ISSN
0378-5173JCR Link
Citation
vol. 194, no. 2, pp. 221 - 227
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The effects of renal failure on the pharmacokinetics of cyclosporine were investigated after intravenous, 30 mg/kg, and oral, 100 mg/kg, administration of the drug using a rat model of uranyl nitrate-induced acute renal failure (U-ARF). After intravenous administration to rats with U-ARF, the volume of distribution at steady state (1.97 vs. 2.56 l/kg) was significantly smaller, and the area under the blood concentration-time curve (348 vs. 296 μg h/ml) tended to be greater and total body clearance (0.0851 vs. 0.102 l/h per kg) tended to be slower than those in control rats. After oral administration, the pharmacokinetic parameters were not significantly different between the control rats and rats with U-ARF, suggesting that U-ARF did not considerably affect the pharmacokinetics of cyclosporine after oral administration. (C) 2000 Elsevier Science B.V.
DOI
10.1016/S0378-5173(99)00382-8
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약학대학 > 약학과 > Journal papers
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