Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구영순 | - |
dc.date.accessioned | 2016-08-28T11:08:22Z | - |
dc.date.available | 2016-08-28T11:08:22Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.other | OAK-361 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218603 | - |
dc.description.abstract | The effects of renal failure on the pharmacokinetics of cyclosporine were investigated after intravenous, 30 mg/kg, and oral, 100 mg/kg, administration of the drug using a rat model of uranyl nitrate-induced acute renal failure (U-ARF). After intravenous administration to rats with U-ARF, the volume of distribution at steady state (1.97 vs. 2.56 l/kg) was significantly smaller, and the area under the blood concentration-time curve (348 vs. 296 μg h/ml) tended to be greater and total body clearance (0.0851 vs. 0.102 l/h per kg) tended to be slower than those in control rats. After oral administration, the pharmacokinetic parameters were not significantly different between the control rats and rats with U-ARF, suggesting that U-ARF did not considerably affect the pharmacokinetics of cyclosporine after oral administration. (C) 2000 Elsevier Science B.V. | - |
dc.language | English | - |
dc.title | Pharmacokinetic changes of cyclosporine after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 194 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 221 | - |
dc.relation.lastpage | 227 | - |
dc.relation.journaltitle | International Journal of Pharmaceutics | - |
dc.identifier.doi | 10.1016/S0378-5173(99)00382-8 | - |
dc.identifier.wosid | WOS:000085018800009 | - |
dc.identifier.scopusid | 2-s2.0-0342545976 | - |
dc.author.google | Lee Y.H. | - |
dc.author.google | Park K.H. | - |
dc.author.google | Ku Y.S. | - |
dc.contributor.scopusid | 구영순(7202602602) | - |
dc.date.modifydate | 20160718162637 | - |