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Phagocytic activity of ethyl alcohol fraction of deer antler in murine peritoneal macrophage

Title
Phagocytic activity of ethyl alcohol fraction of deer antler in murine peritoneal macrophage
Authors
Suh J.-S.Eun J.-S.So J.-N.Seo J.-T.Jhon G.-J.
Ewha Authors
전길자
SCOPUS Author ID
전길자scopus
Issue Date
1999
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
0918-6158JCR Link
Citation
vol. 22, no. 9, pp. 932 - 935
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The mechanism of phagocytic activity of the ethyl alcohol fraction of Cervus nippon (CN-E) was investigated in vivo. The administration of CN-E (100 mg/kg, p.o.) enhanced lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles in murine peritoneal macrophages. Phagocytic activity was suppressed by the treatment of S-nitrosoglutathione (GSNO) which is an exogenous nitric oxide donor depending on the concentration of dose. CN-E suppressed the production of nitric oxide and enhanced the concentration in [Ca2+](i). The enhancement in [Ca2+](i) was diminished by the treatment of EGTA. These results indicate that CN-E enhances the phagocytic activity of murine peritoneal macrophage via a suppression of nitric oxide production and an increase in [Ca2+](i).
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자연과학대학 > 화학·나노과학전공 > Journal papers
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