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Synthesis and antiviral activity of 2′-fluorohexopyranosyl nucleosides

Title
Synthesis and antiviral activity of 2′-fluorohexopyranosyl nucleosides
Authors
Jeong L.S.Lee J.E.Kim H.O.Chun M.W.
Ewha Authors
정낙신
Issue Date
1998
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 21, no. 3, pp. 338 - 343
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
2′-Fluorohexopyranosyl nucleosides 1a and 1b which contained a bioisosteric double bond and a fluorine were synthesized in 12 steps, starting from D-galactose. During diethylaminosulfur trifluoride (DAST) fluorination, retention of stereochemistry was observed through the participation of methoxy or chloro group at the 6-position of the purine base. The final nucleosides 1a and 1b were found to be inactive against HIV-1 and HSV-1,2.
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약학대학 > 약학과 > Journal papers
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