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Controlled release of platelet-derived growth factor from porous poly(L- lactide) membranes for guided tissue regeneration

Title
Controlled release of platelet-derived growth factor from porous poly(L- lactide) membranes for guided tissue regeneration
Authors
Park Y.J.Ku Y.Chung C.P.Lee S.J.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
1998
Journal Title
Journal of Controlled Release
ISSN
0168-3659JCR Link
Citation
vol. 51, no. 2-3, pp. 201 - 211
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Platelet-derived growth factor-BB (PDGF-BB) was incorporated into porous poly (L-lactide) (PLLA) membranes with an aim of improving early bone healing in guided tissue regeneration (GTR) therapy. Porous PDGF-BB loaded membranes were fabricated by coating PDGF-BB-dissolved PLLA methylene chloride-ethyl acetate solutions on polyglycolic acid (PGA) meshes. Release kinetics of PDGF-BB, biologic activity, degradability and guided tissue regenerative potentials of the membranes were investigated. Release of PDGF-BB could be controlled by adding bovine serum albumin that may provide porous diffusion channels for PDGF-BB release and by varying initial loading content of PDGF- BB. Biologic activity of PDGF-BB in the membranes was ascertained by fibroblast chemotaxis. PDGF-BB loaded membranes maintained proper degradation property for periodontal application. PDGF-BB loaded membrane markedly increased new bone formation in rat calvarial defects, and completed bony reunion after 2 weeks of implantation period. These results suggested that PDGF-BB loaded PLLA membrane might potentially enhance guided tissue regenerative efficacy.
DOI
10.1016/S0168-3659(97)00169-7
Appears in Collections:
약학대학 > 약학과 > Journal papers
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