Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-08-28T11:08:03Z | - |
dc.date.available | 2016-08-28T11:08:03Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.other | OAK-14 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218398 | - |
dc.description.abstract | Platelet-derived growth factor-BB (PDGF-BB) was incorporated into porous poly (L-lactide) (PLLA) membranes with an aim of improving early bone healing in guided tissue regeneration (GTR) therapy. Porous PDGF-BB loaded membranes were fabricated by coating PDGF-BB-dissolved PLLA methylene chloride-ethyl acetate solutions on polyglycolic acid (PGA) meshes. Release kinetics of PDGF-BB, biologic activity, degradability and guided tissue regenerative potentials of the membranes were investigated. Release of PDGF-BB could be controlled by adding bovine serum albumin that may provide porous diffusion channels for PDGF-BB release and by varying initial loading content of PDGF- BB. Biologic activity of PDGF-BB in the membranes was ascertained by fibroblast chemotaxis. PDGF-BB loaded membranes maintained proper degradation property for periodontal application. PDGF-BB loaded membrane markedly increased new bone formation in rat calvarial defects, and completed bony reunion after 2 weeks of implantation period. These results suggested that PDGF-BB loaded PLLA membrane might potentially enhance guided tissue regenerative efficacy. | - |
dc.language | English | - |
dc.title | Controlled release of platelet-derived growth factor from porous poly(L- lactide) membranes for guided tissue regeneration | - |
dc.type | Article | - |
dc.relation.issue | 2-3 | - |
dc.relation.volume | 51 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 201 | - |
dc.relation.lastpage | 211 | - |
dc.relation.journaltitle | Journal of Controlled Release | - |
dc.identifier.doi | 10.1016/S0168-3659(97)00169-7 | - |
dc.identifier.wosid | WOS:000072419400012 | - |
dc.identifier.scopusid | 2-s2.0-17744406712 | - |
dc.author.google | Park Y.J. | - |
dc.author.google | Ku Y. | - |
dc.author.google | Chung C.P. | - |
dc.author.google | Lee S.J. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |