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Transactivation potential of the C-terminus of human Nm23-H1

Title
Transactivation potential of the C-terminus of human Nm23-H1
Authors
Chae S.-K.Lee N.-S.Lee K.-J.Kim E.
Ewha Authors
이공주
SCOPUS Author ID
이공주scopus
Issue Date
1998
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 423, no. 2, pp. 235 - 238
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The transactivation potential of Nm23-H1, a homolog of c-myc transcription factor Nm23-H2/PuF was assessed in yeast as a fusion protein with the DNA binding domains (DBDs) of GAL4 and LexA. The C-terminal half of Nm23-H1 exhibited strong transactivation of the reporter genes, LacZ and Leu2 carrying GAL4 and LexA upstream activating sequences (UASs), whereas the full-length Nm23-H1 and its N-terminal did not. Similar results were also obtained with Nm23-H2/PuF transactivating the reporter genes only by the C- terminus fused to GAL4 and LexA DBDs. Hence, our results suggested a possible regulatory role of the N-termini of Nm23 isotypes upon transactivation.
DOI
10.1016/S0014-5793(98)00100-8
Appears in Collections:
약학대학 > 약학과 > Journal papers
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