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A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo

Title
A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo
Authors
Lim, YeniLee, SenaKim, Ji YeonShin, Jae-HoKwon, Oran
Ewha Authors
권오란
SCOPUS Author ID
권오란scopus
Issue Date
2016
Journal Title
JOURNAL OF FUNCTIONAL FOODS
ISSN
1756-4646JCR Link
Citation
vol. 24, pp. 231 - 243
Keywords
Atherothrombotic profileCombination supplement ofPhellinus baumii and Salviamiltiorrhiza BungeEndothelial nitric oxide synthaseCyclooxygenasePlatelet activation model
Publisher
ELSEVIER SCIENCE BV
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Given the high prevalence of atherothrombotic disease and increasing attention to functional foods, we tested the hypothesis that a combination supplement (PS) containing Phellinus baumii (PB) and Salvia miltiorrhiza Bunge (SM) may improve the atherothrombotic profile in rats. The PS (Experiment 1) or PB/SM (Experiment 2) supplement was administered orally once daily for 7 days prior to inducing platelet activation at the last day. Orally administered PS showed an additive and positive effect on nitric oxide (NO) availability, adhesion molecule/pro-inflammatory cytokine release, and thrombosis compared to controls. This effect was attributed more to PB than to SM for cyclooxygenase (COX)-1 and to SM for COX-2. In vitro data revealed that tanshinone IIA derived from SM remarkably suppressed COX-2, and protocatechuic acid derived from PB caused a small increase in NO production. The data suggest the potential use of PS to ameliorate endothelial and vascular dysfunction induced by unintended platelet activation. (c) 2016 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.jff.2016.04.012
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신산업융합대학 > 식품영양학과 > Journal papers
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