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Effects of single nucleotide polymorphisms in c-Myc on stable warfarin doses in patients with cardiac valve replacements

Title
Effects of single nucleotide polymorphisms in c-Myc on stable warfarin doses in patients with cardiac valve replacements
Authors
Lee, Kyung E.Chang, Byung C.Park, SunnyGwak, Hye S.
Ewha Authors
곽혜선
SCOPUS Author ID
곽혜선scopus
Issue Date
2015
Journal Title
PHARMACOGENOMICS
ISSN
1462-2416JCR Link1744-8042JCR Link
Citation
vol. 16, no. 10, pp. 1101 - 1108
Keywords
8q24c-Myctranscription factorVKORC1warfarin
Publisher
FUTURE MEDICINE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
This study aimed to investigate an association between c-Myc SNPs and stable warfarin doses. Materials & methods: The influences of genetic polymorphisms on dose requirements were investigated by genotyping ten SNPs in 201 patients with stable warfarin doses; VKORC1 (rs9923231), CYP2C9 (rs1057910), CYP4F2 (rs2108622), GATA4 (rs10090884), c-Myc (rs4645962, rs4645943, rs4645948 and rs4645974) and 8q24 (rs1447295 and rs16901979). Results: Around 44.3% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; VKORC1 genotype accounted for 26.4%, CYP2C9 genotype for 4.9%, age for 3.4%, c-Myc genotypes for 5.2% (rs4645974 for 2.4% and rs4645943 for 2.8%), CYP4F2 genotype for 2.9% and diuretic use for 1.5%. Conclusion: Our results revealed that c-Myc could be a determinant of stable warfarin doses.
DOI
10.2217/PGS.15.37
Appears in Collections:
약학대학 > 약학과 > Journal papers
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