Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽혜선 | * |
dc.date.accessioned | 2016-08-27T04:08:10Z | - |
dc.date.available | 2016-08-27T04:08:10Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1462-2416 | * |
dc.identifier.issn | 1744-8042 | * |
dc.identifier.other | OAK-15654 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217619 | - |
dc.description.abstract | This study aimed to investigate an association between c-Myc SNPs and stable warfarin doses. Materials & methods: The influences of genetic polymorphisms on dose requirements were investigated by genotyping ten SNPs in 201 patients with stable warfarin doses; VKORC1 (rs9923231), CYP2C9 (rs1057910), CYP4F2 (rs2108622), GATA4 (rs10090884), c-Myc (rs4645962, rs4645943, rs4645948 and rs4645974) and 8q24 (rs1447295 and rs16901979). Results: Around 44.3% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; VKORC1 genotype accounted for 26.4%, CYP2C9 genotype for 4.9%, age for 3.4%, c-Myc genotypes for 5.2% (rs4645974 for 2.4% and rs4645943 for 2.8%), CYP4F2 genotype for 2.9% and diuretic use for 1.5%. Conclusion: Our results revealed that c-Myc could be a determinant of stable warfarin doses. | * |
dc.language | English | * |
dc.publisher | FUTURE MEDICINE LTD | * |
dc.subject | 8q24 | * |
dc.subject | c-Myc | * |
dc.subject | transcription factor | * |
dc.subject | VKORC1 | * |
dc.subject | warfarin | * |
dc.title | Effects of single nucleotide polymorphisms in c-Myc on stable warfarin doses in patients with cardiac valve replacements | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1101 | * |
dc.relation.lastpage | 1108 | * |
dc.relation.journaltitle | PHARMACOGENOMICS | * |
dc.identifier.doi | 10.2217/PGS.15.37 | * |
dc.identifier.wosid | WOS:000361140600007 | * |
dc.identifier.scopusid | 2-s2.0-84941628487 | * |
dc.author.google | Lee, Kyung E. | * |
dc.author.google | Chang, Byung C. | * |
dc.author.google | Park, Sunny | * |
dc.author.google | Gwak, Hye S. | * |
dc.date.modifydate | 20240422115307 | * |