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Synthesis and Evaluation of (4-Chlorobenzhydryl) Piperazine Amides as Sodium Channel Nav1.7 Inhibitors
- Synthesis and Evaluation of (4-Chlorobenzhydryl) Piperazine Amides as Sodium Channel Nav1.7 Inhibitors
- Back, Seung Keun; Kam, Yoo Lim; Oh, Jung Ae; Na, Heung Sik; Ih, Uhtaek; Choo, Hea-Young Park
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- 0253-2964; 1229-5949
- vol. 36, no. 9, pp. 2290 - 2297
- Nav1.7; Voltage Ion Probe Reader assay; Formalin test; Neuropathic pain
- WILEY-V C H VERLAG GMBH
- SCI; SCIE; SCOPUS; KCI
- Blockage of voltage-gated sodium channels is used to treat neuropathic pain which is chronic and can become debilitating. Sodium channels Nav1.7-1.9 are especially attractive targets for drug discovery because of the broad therapeutic potential of their modulation. For a neuropathic pain therapy, anticonvulsant like lamotrigine, carbamazepine and a topical anesthetic such as Lidocaine are used. A growing number of clinical reports suggest that selective inhibitors of Nav1.7 are likely to be the powerful analgesics for treating a broad range of pain conditions. Therefore we evaluated 108 amide derivatives synthesized on human Nav1.7 (hNav1.7) by VIPR (voltage/ion probe reader), a fluorescence image plate reader (FLIPR) assay that used voltage-sensor fluorescence dye and stable HEK-293 cell lines expressing hNaV1.7. Ten compounds demonstrated inhibitory activity, and the two most active compounds (5 and 6) had IC50 values of 8-10 mu M.
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