Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박혜영 | - |
dc.date.accessioned | 2016-08-27T04:08:06Z | - |
dc.date.available | 2016-08-27T04:08:06Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.other | OAK-15586 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217581 | - |
dc.description.abstract | Blockage of voltage-gated sodium channels is used to treat neuropathic pain which is chronic and can become debilitating. Sodium channels Nav1.7-1.9 are especially attractive targets for drug discovery because of the broad therapeutic potential of their modulation. For a neuropathic pain therapy, anticonvulsant like lamotrigine, carbamazepine and a topical anesthetic such as Lidocaine are used. A growing number of clinical reports suggest that selective inhibitors of Nav1.7 are likely to be the powerful analgesics for treating a broad range of pain conditions. Therefore we evaluated 108 amide derivatives synthesized on human Nav1.7 (hNav1.7) by VIPR (voltage/ion probe reader), a fluorescence image plate reader (FLIPR) assay that used voltage-sensor fluorescence dye and stable HEK-293 cell lines expressing hNaV1.7. Ten compounds demonstrated inhibitory activity, and the two most active compounds (5 and 6) had IC50 values of 8-10 mu M. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | Nav1.7 | - |
dc.subject | Voltage Ion Probe Reader assay | - |
dc.subject | Formalin test | - |
dc.subject | Neuropathic pain | - |
dc.title | Synthesis and Evaluation of (4-Chlorobenzhydryl) Piperazine Amides as Sodium Channel Nav1.7 Inhibitors | - |
dc.type | Article | - |
dc.relation.issue | 9 | - |
dc.relation.volume | 36 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 2290 | - |
dc.relation.lastpage | 2297 | - |
dc.relation.journaltitle | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.identifier.doi | 10.1002/bkcs.10446 | - |
dc.identifier.wosid | WOS:000360918600020 | - |
dc.identifier.scopusid | 2-s2.0-84940901251 | - |
dc.author.google | Back, Seung Keun | - |
dc.author.google | Kam, Yoo Lim | - |
dc.author.google | Oh, Jung Ae | - |
dc.author.google | Na, Heung Sik | - |
dc.author.google | Ih, Uhtaek | - |
dc.author.google | Choo, Hea-Young Park | - |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | - |
dc.date.modifydate | 20230411110509 | - |