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Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo

Title
Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo
Authors
Lee, So JinYook, SimmyungYhee, Ji YoungYoon, Hong YeolKim, Myung-GooKu, Sook HeeKim, Sun HwaPark, Jae HyungJeong, Ji HoonKwon, Ick ChanLee, SeulkiLee, HyukjinKim, Kwangmeyung
Ewha Authors
이혁진
SCOPUS Author ID
이혁진scopus
Issue Date
2015
Journal Title
JOURNAL OF CONTROLLED RELEASE
ISSN
0168-3659JCR Link1873-4995JCR Link
Citation
vol. 220, pp. 631 - 641
Keywords
Dual-gene deliveryGlycol chitosanNanoparticlesiRNA polymerTumor targeted delivery
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Cancer is a multifactorial disease which involves complex genetic mutation and dysregulation. Combinatorial RNAi technology and concurrent multiple gene silencing are expected to provide advanced strategies for effective cancer therapy, but a safe and effective carrier system is a prerequisite to successful siRNA delivery in vivo. We previously developed an effective tumor-targeting siRNA delivery system for in vivo application. In response to the success of this development, herein we present a dual-gene targeted siRNA and its delivery system, to achieve synergistic effects in cancer therapy. Two different sequences of siRNA were chemically modified to be randomly copolymerized in a single backbone of siRNA polymer (Dual-poly-siRNA), and the resulting Dual-poly-siRNA was incorporated into tumor-homing glycol chitosan nanoparticles. Based on the stability in serum and delivery in a tumor-targeted manner, intravenously administered Dual-poly-siRNA carrying glycol chitosan nanoparticles (Dual-NP) demonstrated successful dual-gene silencing in tumors. Notably, co-delivery of VEGF and Bcl-2 targeting siRNA led to more effective cancer therapy for convenient application. (C) 2015 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jconrel.2015.08.032
Appears in Collections:
약학대학 > 약학과 > Journal papers
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