Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혁진 | * |
dc.date.accessioned | 2016-08-27T04:08:06Z | - |
dc.date.available | 2016-08-27T04:08:06Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0168-3659 | * |
dc.identifier.issn | 1873-4995 | * |
dc.identifier.other | OAK-15581 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217578 | - |
dc.description.abstract | Cancer is a multifactorial disease which involves complex genetic mutation and dysregulation. Combinatorial RNAi technology and concurrent multiple gene silencing are expected to provide advanced strategies for effective cancer therapy, but a safe and effective carrier system is a prerequisite to successful siRNA delivery in vivo. We previously developed an effective tumor-targeting siRNA delivery system for in vivo application. In response to the success of this development, herein we present a dual-gene targeted siRNA and its delivery system, to achieve synergistic effects in cancer therapy. Two different sequences of siRNA were chemically modified to be randomly copolymerized in a single backbone of siRNA polymer (Dual-poly-siRNA), and the resulting Dual-poly-siRNA was incorporated into tumor-homing glycol chitosan nanoparticles. Based on the stability in serum and delivery in a tumor-targeted manner, intravenously administered Dual-poly-siRNA carrying glycol chitosan nanoparticles (Dual-NP) demonstrated successful dual-gene silencing in tumors. Notably, co-delivery of VEGF and Bcl-2 targeting siRNA led to more effective cancer therapy for convenient application. (C) 2015 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE BV | * |
dc.subject | Dual-gene delivery | * |
dc.subject | Glycol chitosan | * |
dc.subject | Nanoparticle | * |
dc.subject | siRNA polymer | * |
dc.subject | Tumor targeted delivery | * |
dc.title | Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo | * |
dc.type | Article | * |
dc.relation.volume | 220 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 631 | * |
dc.relation.lastpage | 641 | * |
dc.relation.journaltitle | JOURNAL OF CONTROLLED RELEASE | * |
dc.identifier.doi | 10.1016/j.jconrel.2015.08.032 | * |
dc.identifier.wosid | WOS:000368021100009 | * |
dc.identifier.scopusid | 2-s2.0-84949529212 | * |
dc.author.google | Lee, So Jin | * |
dc.author.google | Yook, Simmyung | * |
dc.author.google | Yhee, Ji Young | * |
dc.author.google | Yoon, Hong Yeol | * |
dc.author.google | Kim, Myung-Goo | * |
dc.author.google | Ku, Sook Hee | * |
dc.author.google | Kim, Sun Hwa | * |
dc.author.google | Park, Jae Hyung | * |
dc.author.google | Jeong, Ji Hoon | * |
dc.author.google | Kwon, Ick Chan | * |
dc.author.google | Lee, Seulki | * |
dc.author.google | Lee, Hyukjin | * |
dc.author.google | Kim, Kwangmeyung | * |
dc.contributor.scopusid | 이혁진(55233457200) | * |
dc.date.modifydate | 20240220111730 | * |