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Misassigned natural products and their revised structures

Title
Misassigned natural products and their revised structures
Authors
Yoo, Hye-DongNam, Sang-JipChin, Young-WonKim, Min-Sun
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2016
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link1976-3786JCR Link
Citation
vol. 39, no. 2, pp. 143 - 153
Keywords
Natural productNMRStructure determinationStructure-activity relationshipDrug developmentPK/PD
Publisher
PHARMACEUTICAL SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Natural products are a major pipeline for drug development and are responsible for more than 50 % of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide unambiguous chemical structure information on natural products in drug development research, including the structure-activity relationship, derivatization and pharmacokinetic/pharmacodynamic studies. Advancement of NMR instruments has made it possible to deal with nanomole-scale natural products for structure elucidation, but misinterpretation of NMR spectra still occurs. We review 21 natural products with revised chemical structures and the methods used for those revisions.
DOI
10.1007/s12272-015-0649-9
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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