View : 78 Download: 7

A New 9,10-Dihydrophenanthrene and Cell Proliferative 3,4-delta-Dehydrotocopherols from Stemona tuberosa

Title
A New 9,10-Dihydrophenanthrene and Cell Proliferative 3,4-delta-Dehydrotocopherols from Stemona tuberosa
Authors
Kil, Yun-SeoPark, JiyoungHan, Ah-ReumWoo, Hyun AeSeo, Eun-Kyoung
Ewha Authors
서은경한아름우현애
SCOPUS Author ID
서은경scopus; 한아름scopusscopus; 우현애scopus
Issue Date
2015
Journal Title
MOLECULES
ISSN
1420-3049JCR Link
Citation
vol. 20, no. 4, pp. 5965 - 5974
Keywords
Stemona tuberosaStemonaceae910-dihydrophenanthrene34--dehydrotocopherolchiral separationcell proliferation
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A new compound, 9,10-dihydro-5-methoxy-8-methyl-2,7-phenanthrenediol (1), was isolated from the roots of Stemona tuberosa Lour. (Stemonaceae) together with two new optically active compounds, (2S,4'R,8'R)-3,4--dehydrotocopherol (2) and (2R,4'R,8'R)-3,4--dehydrotocopherol (3). The structures of compounds 1-3 were determined on the basis of spectroscopic data analysis. Compounds 2 and 3 were each purified from a stereoisomeric mixture of 2 and 3 by preparative HPLC using a chiral column for the first time. The absolute configurations at C-2 of 2 and 3 were determined by Circular Dichroism (CD) experiments. As a part of the research to find natural wound healing agents, all isolates and the mixture of 2 and 3 were evaluated for their cell proliferative effects using a mouse fibroblast NIH3T3 and a HeLa human cervical cancer cell line. As a result, 1, 2, 3, or the mixture of 2 and 3 showed 41.6%, 78.4%, 118.6%, 38.2% increases of cell proliferation in the mouse fibroblast NIH3T3 respectively, compared to 28.4% increase of -tocopherol. Moreover, none of them induced cancer cell proliferation. Therefore, 3,4--dehydrotocopherols, especially pure isomers 2 and 3 can be suggested as potential wound healing agents.
DOI
10.3390/molecules20045965
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
001.pdf(801.31 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE