Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 한아름 | * |
dc.contributor.author | 우현애 | * |
dc.date.accessioned | 2016-08-27T04:08:36Z | - |
dc.date.available | 2016-08-27T04:08:36Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1420-3049 | * |
dc.identifier.other | OAK-15052 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217278 | - |
dc.description.abstract | A new compound, 9,10-dihydro-5-methoxy-8-methyl-2,7-phenanthrenediol (1), was isolated from the roots of Stemona tuberosa Lour. (Stemonaceae) together with two new optically active compounds, (2S,4'R,8'R)-3,4--dehydrotocopherol (2) and (2R,4'R,8'R)-3,4--dehydrotocopherol (3). The structures of compounds 1-3 were determined on the basis of spectroscopic data analysis. Compounds 2 and 3 were each purified from a stereoisomeric mixture of 2 and 3 by preparative HPLC using a chiral column for the first time. The absolute configurations at C-2 of 2 and 3 were determined by Circular Dichroism (CD) experiments. As a part of the research to find natural wound healing agents, all isolates and the mixture of 2 and 3 were evaluated for their cell proliferative effects using a mouse fibroblast NIH3T3 and a HeLa human cervical cancer cell line. As a result, 1, 2, 3, or the mixture of 2 and 3 showed 41.6%, 78.4%, 118.6%, 38.2% increases of cell proliferation in the mouse fibroblast NIH3T3 respectively, compared to 28.4% increase of -tocopherol. Moreover, none of them induced cancer cell proliferation. Therefore, 3,4--dehydrotocopherols, especially pure isomers 2 and 3 can be suggested as potential wound healing agents. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | Stemona tuberosa | * |
dc.subject | Stemonaceae | * |
dc.subject | 9 | * |
dc.subject | 10-dihydrophenanthrene | * |
dc.subject | 3 | * |
dc.subject | 4--dehydrotocopherol | * |
dc.subject | chiral separation | * |
dc.subject | cell proliferation | * |
dc.title | A New 9,10-Dihydrophenanthrene and Cell Proliferative 3,4-delta-Dehydrotocopherols from Stemona tuberosa | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5965 | * |
dc.relation.lastpage | 5974 | * |
dc.relation.journaltitle | MOLECULES | * |
dc.identifier.doi | 10.3390/molecules20045965 | * |
dc.identifier.wosid | WOS:000354480700043 | * |
dc.identifier.scopusid | 2-s2.0-84928668428 | * |
dc.author.google | Kil, Yun-Seo | * |
dc.author.google | Park, Jiyoung | * |
dc.author.google | Han, Ah-Reum | * |
dc.author.google | Woo, Hyun Ae | * |
dc.author.google | Seo, Eun-Kyoung | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.contributor.scopusid | 우현애(8068619500) | * |
dc.date.modifydate | 20240215164922 | * |