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Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells

Title
Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells
Authors
Lee, Mak-SoonKim, Chong-TaiKim, In-HwanKim, Yangha
Ewha Authors
김양하
SCOPUS Author ID
김양하scopus
Issue Date
2015
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN
0916-8451JCR Link1347-6947JCR Link
Citation
vol. 79, no. 5, pp. 816 - 819
Keywords
Korean red ginseng water extract (KRGE)3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductasehepatic lipid accumulationfatty acid synthase (FAS)HepG2 cells
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells.
DOI
10.1080/09168451.2014.997186
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신산업융합대학 > 식품영양학과 > Journal papers
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