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Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge Monanchora sp.

Title
Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge Monanchora sp.
Authors
Wang, WeihongLee, Tae GuPatil, Rahul S.Mun, BoraYang, InhoKim, HiyoungHahn, DongyupWon, Dong HwanLee, JihyeLee, YeheeChoi, HyukjaeNam, Sang-JipKang, Heonjoong
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2015
Journal Title
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864JCR Link1520-6025JCR Link
Citation
vol. 78, no. 3, pp. 368 - 373
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-alpha, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.
DOI
10.1021/np500760v
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자연과학대학 > 화학·나노과학전공 > Journal papers
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