Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2016-08-27T04:08:18Z | - |
dc.date.available | 2016-08-27T04:08:18Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0163-3864 | * |
dc.identifier.issn | 1520-6025 | * |
dc.identifier.other | OAK-14707 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217094 | - |
dc.description.abstract | Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-alpha, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge Monanchora sp. | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 78 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 368 | * |
dc.relation.lastpage | 373 | * |
dc.relation.journaltitle | JOURNAL OF NATURAL PRODUCTS | * |
dc.identifier.doi | 10.1021/np500760v | * |
dc.identifier.wosid | WOS:000352033900005 | * |
dc.author.google | Wang, Weihong | * |
dc.author.google | Lee, Tae Gu | * |
dc.author.google | Patil, Rahul S. | * |
dc.author.google | Mun, Bora | * |
dc.author.google | Yang, Inho | * |
dc.author.google | Kim, Hiyoung | * |
dc.author.google | Hahn, Dongyup | * |
dc.author.google | Won, Dong Hwan | * |
dc.author.google | Lee, Jihye | * |
dc.author.google | Lee, Yehee | * |
dc.author.google | Choi, Hyukjae | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Kang, Heonjoong | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |