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Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers

Title
Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers
Authors
Ullapu, Punna ReddyKu, Su JinChoi, Yeon HeePark, JiyeonHan, So-YeopBaek, Du JongLee, JaekyunPae, Ae NimMin, Sun-JoonCho, Yong Seo
Ewha Authors
한소엽
SCOPUS Author ID
한소엽scopus
Issue Date
2011
Journal Title
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
ISSN
0253-2964JCR Link
Citation
vol. 32, no. 8, pp. 3063 - 3073
Keywords
T-type calcium channel blockers1,4-DiazepanesHeteroaromatic compoundsFDSS6000 assayPatch-clamp assay
Publisher
KOREAN CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS; KCI WOS
Abstract
The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 211 exhibiting the most potent T-type calcium channel blocking activity with IC(50) value of 0.20 mu M, which is superior to that of mibefradil.
DOI
10.5012/bkcs.2011.32.8.3063
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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