DSpace at EWHA: Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers

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DC Field	Value	Language
dc.contributor.author	한소엽	-
dc.date.accessioned	2016-08-27T02:08:19Z	-
dc.date.available	2016-08-27T02:08:19Z	-
dc.date.issued	2011	-
dc.identifier.issn	0253-2964	-
dc.identifier.other	OAK-8176	-
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/216565	-
dc.description.abstract	The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 211 exhibiting the most potent T-type calcium channel blocking activity with IC(50) value of 0.20 mu M, which is superior to that of mibefradil.	-
dc.language	English	-
dc.publisher	KOREAN CHEMICAL SOC	-
dc.subject	T-type calcium channel blockers	-
dc.subject	1,4-Diazepanes	-
dc.subject	Heteroaromatic compounds	-
dc.subject	FDSS6000 assay	-
dc.subject	Patch-clamp assay	-
dc.title	Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers	-
dc.type	Article	-
dc.relation.issue	8	-
dc.relation.volume	32	-
dc.relation.index	SCI	-
dc.relation.index	SCIE	-
dc.relation.index	SCOPUS	-
dc.relation.index	KCI	-
dc.relation.startpage	3063	-
dc.relation.lastpage	3073	-
dc.relation.journaltitle	BULLETIN OF THE KOREAN CHEMICAL SOCIETY	-
dc.identifier.doi	10.5012/bkcs.2011.32.8.3063	-
dc.identifier.wosid	WOS:000297383700048	-
dc.author.google	Ullapu, Punna Reddy	-
dc.author.google	Ku, Su Jin	-
dc.author.google	Choi, Yeon Hee	-
dc.author.google	Park, Jiyeon	-
dc.author.google	Han, So-Yeop	-
dc.author.google	Baek, Du Jong	-
dc.author.google	Lee, Jaekyun	-
dc.author.google	Pae, Ae Nim	-
dc.author.google	Min, Sun-Joon	-
dc.author.google	Cho, Yong Seo	-
dc.contributor.scopusid	한소엽(7405944194)	-
dc.date.modifydate	20200928112844	-