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A Synthesis of Oseltamivir (Tamiflu) Starting from D-Mannitol

Title
A Synthesis of Oseltamivir (Tamiflu) Starting from D-Mannitol
Authors
Ko, Ji S.Keum, Ji E.Ko, Soo Y.
Ewha Authors
고수영
SCOPUS Author ID
고수영scopus
Issue Date
2010
Journal Title
JOURNAL OF ORGANIC CHEMISTRY
ISSN
0022-3263JCR Link
Citation
vol. 75, no. 20, pp. 7006 - 7009
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A sythesis oseltamivir (Tamiflu) was achieved starting from D-mannitol A unique feature of the synthetic route is that an acyelic processor was constructed which was then cyclized in an ultramolecular aldol reaction to form the Tamiflu skeletion Throughout the synthesis well-established. highly efficient reactions were employed, and no protecion/deprotection sequence was needed
DOI
10.1021/jo.101517g
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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