A Synthesis of Oseltamivir (Tamiflu) Starting from D-Mannitol

Abstract

A sythesis oseltamivir (Tamiflu) was achieved starting from D-mannitol A unique feature of the synthetic route is that an acyelic processor was constructed which was then cyclized in an ultramolecular aldol reaction to form the Tamiflu skeletion Throughout the synthesis well-established. highly efficient reactions were employed, and no protecion/deprotection sequence was needed