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dc.contributor.author김양하-
dc.date.accessioned2016-08-27T02:08:08Z-
dc.date.available2016-08-27T02:08:08Z-
dc.date.issued2010-
dc.identifier.issn1976-1457-
dc.identifier.otherOAK-6698-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/216449-
dc.description.abstractThere is an increasing interest in curcumin (Curcurna longa L.) as a cardiovascular disease (CVD) protective agent via decreased blood total cholesterol and low-density lipoprotein-cholesterol (LDL-cholesterol) level. The aim of this study was to investigate further the potential mechanism in the hypocholesterolemic effect of curcumin by measuring cholesterol 7a-hydroxylase (CYP7A1), a rate limiting enzyme in the biosynthesis of bile acid from cholesterol, at the mRNA level. Male Sprague-Dawley rats were fed a 45% high fat diet or same diet supplemented with curcumin (0.1% wt/wt) for 8 weeks. The curcumin diet significantly decreased serum triglyceride (TG) by 27%, total cholesterol (TC) by 33.8%, and LDL-cholesterol by 56%, respectively as compared to control group. The curcumin-supplemented diet also significantly lowered the atherogenic index (AI) by 48% as compared to control group. Hepatic TG level was significantly reduced by 41% in rats fed with curcumin-supplemented diet in comparison with control group (P < 0.05). Conversely, the curcumin diet significantly increased fecal TG and TC. The curcumin diet up-regulated hepatic CYP7A1 mRNA level by 2.16-fold, compared to control group p (P < 0.05). These findings suggested that the increases in the CYP7A1 gene expression may partially account for the hypocholesterolemic effect of curcumin.-
dc.languageEnglish-
dc.publisherKOREAN NUTRITION SOC-
dc.subjectCurcumin-
dc.subjectcholesterol-
dc.subjectCYP7A1-
dc.subjectmRNA-
dc.subjectrat-
dc.titleHypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume4-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage191-
dc.relation.lastpage195-
dc.relation.journaltitleNUTRITION RESEARCH AND PRACTICE-
dc.identifier.doi10.4162/nrp.2010.4.3.191-
dc.identifier.wosidWOS:000279525300003-
dc.author.googleKim, Minji-
dc.author.googleKim, Yangha-
dc.contributor.scopusid김양하(8524160300)-
dc.date.modifydate20170508110102-
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신산업융합대학 > 식품영양학과 > Journal papers
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