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Effect of dietary folate on hyperhomocysteinemia and cellular toxicity induced alcohol administration in rat liver

Title
Effect of dietary folate on hyperhomocysteinemia and cellular toxicity induced alcohol administration in rat liver
Authors
Kim, Chung HyeonKim, Ki NamKim, YeonsooChang, Namsoo
Ewha Authors
장남수김기남
SCOPUS Author ID
장남수scopus
Issue Date
2005
Journal Title
MOLECULAR & CELLULAR TOXICOLOGY
ISSN
1738-642XJCR Link
Citation
vol. 1, no. 2, pp. 137 - 141
Keywords
liver cellular toxicityhomocysteinealcoholdietary folateliver folate
Publisher
KOREAN SOC TOXICOGENOMICS & TOXICOPROTEOMICS
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
The critical role of folate in the remethylation pathway for methionine synthesis from homocysteine has been well documented. Hyperhomocysteinemia resulting from inadequate folate nutrition has been implicated in increased incidence of macrovascular diseases, colorectal cancer, neural tube defects, etc. Chronic exposure to ethanol impairs folate nutrition and one-carbon metabolism in the liver, which often results in fatty liver due to a defective remetylation process. This study was carried out to investigate the chronic effects of moderate levels of alcohol and dietary folate on plasma homocysteine levels, and on histopathology and biochemical functions of the liver. Rats were raised on experimental diets with three levels of folate (0, 2, 8 mg/kg diet), and 50% ethanol (1.8 ml/kg body weight) was administered intragastically by intubation tubes three times a week for 10 weeks. Plasma homocysteine concentrations were found to be significantly influenced by dietary folate intake and alcohol administration. Among all treatment groups, plasma homocysteine levels were the highest in the animals receiving a combined treatment of folate deficient diet and alcohol administration. Plasma homocysteine concentrations were negatively correlated with folate concentration in the plasma (p<0.01) and liver (p<0.05). Among alcohol treated rats, increase in plasma homocysteine values due to macrovascular and microvascular fatty changes and spotted necrosis were observed more frequently in folate-deficient animals diet than those on folate-adequate and folate supplemented diets in alcohol-treated rats. These results indicate that folate supplementation above the recommended level might be beneficial in the prevention of alcohol-related hyperhomocysteinemia and abnormal histologic changes in the liver.
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신산업융합대학 > 식품영양학과 > Journal papers
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