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Carboxyl-terminus of the amyloid protein precursor and ERB are required for estrogenic effect in activating mitogen-activated protein kinase

Title
Carboxyl-terminus of the amyloid protein precursor and ERB are required for estrogenic effect in activating mitogen-activated protein kinase
Authors
Lim, HJLim, CJHwang, DYLee, SHMin, SHSong, YSSeo, SJPark, HKSheen, YYCho, JSKim, YK
Ewha Authors
신윤용
SCOPUS Author ID
신윤용scopus
Issue Date
2004
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN
1107-3756JCR Link
Citation
vol. 13, no. 5, pp. 691 - 696
Keywords
estrogenestrogen receptormitogen activated protein kinaseAPP C-terminal
Publisher
PROFESSOR D A SPANDIDOS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Estrogen influences the processing of the amyloid beta precursor protein (APP) in the pathogenesis of Alzheimer's disease, and this effect is mediated by estrogen receptors (ERs) in activating mitogen-activated protein kinase (MAPK)-signaling pathway. To test whether the estrogenic effect on both carboxyl-terminal amino acid fragment (C-terminal) of APP (APP-C105)- and ERbeta-mediated MAPK activation in in vitro, two hybrid genes containing each human ERbeta and APP-C105 gene fused to the neuron-specific enolase (NSE) promoter were constructed and were transfected to the neuronal SK-N-MC cells. Western blot shows that the activation of JNK-signaling pathway, but not p38 and ERK, is dependent on ERbeta through estrogen treatment and APP-C105 is also mediated through estrogen in activating MAPK-signaling pathway. The results suggest that ERbeta and APP-C105 derived from APP are necessary for estrogenic effect in activating MAPK-signaling pathway.
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약학대학 > 약학과 > Journal papers
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