Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | - |
dc.date.accessioned | 2016-08-27T02:08:09Z | - |
dc.date.available | 2016-08-27T02:08:09Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.other | OAK-2117 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215804 | - |
dc.description.abstract | Estrogen influences the processing of the amyloid beta precursor protein (APP) in the pathogenesis of Alzheimer's disease, and this effect is mediated by estrogen receptors (ERs) in activating mitogen-activated protein kinase (MAPK)-signaling pathway. To test whether the estrogenic effect on both carboxyl-terminal amino acid fragment (C-terminal) of APP (APP-C105)- and ERbeta-mediated MAPK activation in in vitro, two hybrid genes containing each human ERbeta and APP-C105 gene fused to the neuron-specific enolase (NSE) promoter were constructed and were transfected to the neuronal SK-N-MC cells. Western blot shows that the activation of JNK-signaling pathway, but not p38 and ERK, is dependent on ERbeta through estrogen treatment and APP-C105 is also mediated through estrogen in activating MAPK-signaling pathway. The results suggest that ERbeta and APP-C105 derived from APP are necessary for estrogenic effect in activating MAPK-signaling pathway. | - |
dc.language | English | - |
dc.publisher | PROFESSOR D A SPANDIDOS | - |
dc.subject | estrogen | - |
dc.subject | estrogen receptor | - |
dc.subject | mitogen activated protein kinase | - |
dc.subject | APP C-terminal | - |
dc.title | Carboxyl-terminus of the amyloid protein precursor and ERB are required for estrogenic effect in activating mitogen-activated protein kinase | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 13 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 691 | - |
dc.relation.lastpage | 696 | - |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.identifier.wosid | WOS:000220777800013 | - |
dc.author.google | Lim, HJ | - |
dc.author.google | Lim, CJ | - |
dc.author.google | Hwang, DY | - |
dc.author.google | Lee, SH | - |
dc.author.google | Min, SH | - |
dc.author.google | Song, YS | - |
dc.author.google | Seo, SJ | - |
dc.author.google | Park, HK | - |
dc.author.google | Sheen, YY | - |
dc.author.google | Cho, JS | - |
dc.author.google | Kim, YK | - |
dc.contributor.scopusid | 신윤용(6603872711) | - |
dc.date.modifydate | 20230411104830 | - |