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여로 알카로이드 항균작용에 관한 연구

Title
여로 알카로이드 항균작용에 관한 연구
Authors
한용봉
Issue Date
1973
Department/Major
대학원 약학과
Publisher
이화여자대학교 대학원
Degree
Doctor
Abstract
Three antimicrobial alkaloids were isolated from Veratrum grandiflorum (Maxim) Loes. fil. and identified as veratramine, jervine and pseudojervine. Veratrobasine, isorubijervine, protoveratrine A and B were also detected by TLC, out of which protoveratrine A and B exhibited no antimicrobial action. Of several alkaloids tested, only jerveratrum alkaloids exhibited antimicrobial action ; jervine, pseudojervine, veratrobasine, isorubijervine and veratramine in decreasing order, were effective against Pityrosporum ovale and pseudojervine, jervine, veratramine, veratrobasine and isorubijervine against Trichophyton mentagrophytes. These results and together with the fact that solanidine is inactive against fungi suggest that oxigenation at C-11 for C-nor D-homo steroidal alkaloids and at C-18 for normal steroidal alkaloids plays an important role in activity.
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일반대학원 > 생명·약학부 > Theses_Ph.D
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