Advances and resistance adaptation in BTK-targeted therapy for B-cell malignancies

Abstract

Bruton's tyrosine kinase (BTK) is a key signaling component downstream of the B-cell receptor (BCR) and plays an essential role in the survival and proliferation of multiple B-cell malignancies, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldenstro & uml;m macroglobulinemia (WM). BTK inhibitors (BTKi) have demonstrated substantial clinical benefit and are now widely incorporated into frontline treatment strategies. However, the long-term effectiveness of BTKi is frequently limited by the emergence of both intrinsic