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Conducting polymer-based scaffolds for neuronal tissue engineering
- Title
- Conducting polymer-based scaffolds for neuronal tissue engineering
- Authors
- Yi; Hagje; Patel; Rajkumar; Kapil D.; Bouchard; Louis-S.; Jha; Amitabh; Perriman; Adam Willis; Madhumita
- Ewha Authors
- Madhumita Patel
- SCOPUS Author ID
- Madhumita Patel
- Issue Date
- 2023
- Journal Title
- Journal of Materials Chemistry B
- ISSN
- 2050-750X
- Citation
- Journal of Materials Chemistry B vol. 11, no. 46, pp. 11006 - 11023
- Publisher
- Royal Society of Chemistry
- Indexed
- SCOPUS
- Document Type
- Review
- Abstract
- Neuronal tissue engineering has immense potential for treating neurological disorders and facilitating nerve regeneration. Conducting polymers (CPs) have emerged as a promising class of materials owing to their unique electrical conductivity and biocompatibility. CPs, such as poly(3,4-ethylenedioxythiophene) (PEDOT), poly(3-hexylthiophene) (P3HT), polypyrrole (PPy), and polyaniline (PANi), have been extensively explored for their ability to provide electrical cues to neural cells. These polymers are widely used in various forms, including porous scaffolds, hydrogels, and nanofibers, and offer an ideal platform for promoting cell adhesion, differentiation, and axonal outgrowth. CP-based scaffolds can also serve as drug delivery systems, enabling localized and controlled release of neurotrophic factors and therapeutic agents to enhance neural regeneration and repair. CP-based scaffolds have demonstrated improved neural regeneration, both in vitro and in vivo, for treating spinal cord and peripheral nerve injuries. In this review, we discuss synthesis and scaffold processing methods for CPs and their applications in neuronal tissue regeneration. We focused on a detailed literature review of the central and peripheral nervous systems. © 2023 The Royal Society of Chemistry.
- DOI
- 10.1039/d3tb01838e
- Appears in Collections:
- 연구기관 > 나노바이오·에너지소재센터 > Journal papers
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