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A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study
- Title
- A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study
- Authors
- Shim; Ji-Su; Kim; Hyunkyoung; Kwon; Jae-Woo; Park; So-Young; Sujeong; Byung-Keun; Nam; Young-Hee; Yang; Min-Suk; Mi-Yeong; Sae-Hoon; Lee; Byung-Jae; Taehoon; Sang-Ha; So Young; Cho; Young-Joo; Chan Sun; Jung; Han-Ki; Joo-Hee; Choi; Jeong-Hee; Moon; Ji-Yong; Adcock; Ian; Chung; Kian Fan; Min-Hye; Tae-Bum
- Ewha Authors
- 김민혜; 심지수
- SCOPUS Author ID
- 김민혜; 심지수
- Issue Date
- 2023
- Journal Title
- World Allergy Organization Journal
- ISSN
- 1939-4551
- Citation
- World Allergy Organization Journal vol. 16, no. 12
- Keywords
- Asthma; Asthma-COPD overlap; Biologics; Monoclonal antibodies; Treatment response
- Publisher
- Elsevier Inc.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Despite the increasing use of biologics in severe asthma, there is limited research on their use in asthma-chronic obstructive pulmonary disease overlap (ACO). We compared real-world treatment responses to biologics in ACO and asthma. Methods: We conducted a multicenter, retrospective, cohort study using data from the Precision Medicine Intervention in Severe Asthma (PRISM). ACO was defined as post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.7 and a smoking history of >10 pack-years. Physicians selected biologics (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) based on each United States Food & Drug Administration (FDA) approval criteria. Results: After six-month treatment with biologics, both patients with ACO (N = 13) and asthma (N = 81) showed positive responses in FEV1 (10.69 ± 17.17 vs. 11.25 ± 12.87 %, P = 0.652), Asthma Control Test score (3.33 ± 5.47 vs. 5.39 ± 5.42, P = 0.290), oral corticosteroid use (−117.50 ± 94.38 vs. −115.06 ± 456.85 mg, P = 0.688), fractional exhaled nitric oxide levels (−18.62 ± 24.68 vs. −14.66 ± 45.35 ppb, P = 0.415), sputum eosinophils (−3.40 ± 10.60 vs. −14.48 ± 24.01 %, P = 0.065), blood eosinophils (−36.47 ± 517.02 vs. −363.22 ± 1294.59, P = 0.013), and exacerbation frequency (−3.07 ± 4.42 vs. −3.19 ± 5.11, P = 0.943). The odds ratio for exacerbation and time-to-first exacerbation showed no significant difference after full adjustments, and subgroup analysis according to biologic type was also showed similar results. Conclusions: Biologics treatment response patterns in patients with ACO and asthma were comparable, suggesting that biologics should be actively considered for ACO patients as well. © 2023 The Author(s)
- DOI
- 10.1016/j.waojou.2023.100848
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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