Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김민혜 | * |
dc.contributor.author | 심지수 | * |
dc.date.accessioned | 2024-02-06T16:31:12Z | - |
dc.date.available | 2024-02-06T16:31:12Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1939-4551 | * |
dc.identifier.other | OAK-34550 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267029 | - |
dc.description.abstract | Background: Despite the increasing use of biologics in severe asthma, there is limited research on their use in asthma-chronic obstructive pulmonary disease overlap (ACO). We compared real-world treatment responses to biologics in ACO and asthma. Methods: We conducted a multicenter, retrospective, cohort study using data from the Precision Medicine Intervention in Severe Asthma (PRISM). ACO was defined as post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.7 and a smoking history of >10 pack-years. Physicians selected biologics (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) based on each United States Food & Drug Administration (FDA) approval criteria. Results: After six-month treatment with biologics, both patients with ACO (N = 13) and asthma (N = 81) showed positive responses in FEV1 (10.69 ± 17.17 vs. 11.25 ± 12.87 %, P = 0.652), Asthma Control Test score (3.33 ± 5.47 vs. 5.39 ± 5.42, P = 0.290), oral corticosteroid use (−117.50 ± 94.38 vs. −115.06 ± 456.85 mg, P = 0.688), fractional exhaled nitric oxide levels (−18.62 ± 24.68 vs. −14.66 ± 45.35 ppb, P = 0.415), sputum eosinophils (−3.40 ± 10.60 vs. −14.48 ± 24.01 %, P = 0.065), blood eosinophils (−36.47 ± 517.02 vs. −363.22 ± 1294.59, P = 0.013), and exacerbation frequency (−3.07 ± 4.42 vs. −3.19 ± 5.11, P = 0.943). The odds ratio for exacerbation and time-to-first exacerbation showed no significant difference after full adjustments, and subgroup analysis according to biologic type was also showed similar results. Conclusions: Biologics treatment response patterns in patients with ACO and asthma were comparable, suggesting that biologics should be actively considered for ACO patients as well. © 2023 The Author(s) | * |
dc.language | English | * |
dc.publisher | Elsevier Inc. | * |
dc.subject | Asthma | * |
dc.subject | Asthma-COPD overlap | * |
dc.subject | Biologics | * |
dc.subject | Monoclonal antibodies | * |
dc.subject | Treatment response | * |
dc.title | A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | World Allergy Organization Journal | * |
dc.identifier.doi | 10.1016/j.waojou.2023.100848 | * |
dc.identifier.wosid | WOS:001137305100001 | * |
dc.identifier.scopusid | 2-s2.0-85179602016 | * |
dc.author.google | Shim | * |
dc.author.google | Ji-Su | * |
dc.author.google | Kim | * |
dc.author.google | Hyunkyoung | * |
dc.author.google | Kwon | * |
dc.author.google | Jae-Woo | * |
dc.author.google | Park | * |
dc.author.google | So-Young | * |
dc.author.google | Sujeong | * |
dc.author.google | Byung-Keun | * |
dc.author.google | Nam | * |
dc.author.google | Young-Hee | * |
dc.author.google | Yang | * |
dc.author.google | Min-Suk | * |
dc.author.google | Mi-Yeong | * |
dc.author.google | Sae-Hoon | * |
dc.author.google | Lee | * |
dc.author.google | Byung-Jae | * |
dc.author.google | Taehoon | * |
dc.author.google | Sang-Ha | * |
dc.author.google | So Young | * |
dc.author.google | Cho | * |
dc.author.google | Young-Joo | * |
dc.author.google | Chan Sun | * |
dc.author.google | Jung | * |
dc.author.google | Han-Ki | * |
dc.author.google | Joo-Hee | * |
dc.author.google | Choi | * |
dc.author.google | Jeong-Hee | * |
dc.author.google | Moon | * |
dc.author.google | Ji-Yong | * |
dc.author.google | Adcock | * |
dc.author.google | Ian | * |
dc.author.google | Chung | * |
dc.author.google | Kian Fan | * |
dc.author.google | Min-Hye | * |
dc.author.google | Tae-Bum | * |
dc.contributor.scopusid | 김민혜(58045929900) | * |
dc.contributor.scopusid | 심지수(57193221759) | * |
dc.date.modifydate | 20240315131743 | * |