View : 128 Download: 0
Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness
- Title
- Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness
- Authors
- Yoon; Seo Yeon; Lee; Sang Chul; Suh; Jee Hyun; Yang; Seung Nam; Han; Kyungdo; Kim; Yong Wook
- Ewha Authors
- 서지현
- SCOPUS Author ID
- 서지현
- Issue Date
- 2024
- Journal Title
- npj Parkinson's Disease
- ISSN
- 2373-8057
- Citation
- npj Parkinson's Disease vol. 10, no. 1
- Publisher
- Nature Research
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We aimed to investigate the association of various mental illnesses, including depression, bipolar disorder, schizophrenia, insomnia, and anxiety, with the risk of early-onset Parkinson’s disease (EOPD) (age <50 years) and compare it with that of late-onset PD (LOPD) (age ≥50 years). This nationwide cohort study enrolled 9,920,522 people who underwent a national health screening examination in 2009, and followed up until 31 December 2018. There was a significantly increased risk of EOPD and LOPD in individuals with mental illness, and EOPD showed a stronger association than LOPD (EOPD, hazard ratio (HR) = 3.11, 95% CI: 2.61‒3.72; LOPD, HR = 1.70, 95% CI: 1.66‒1.74; p for interaction <0.0001). Our results suggest that people with mental illnesses aged < 50 years are at a higher risk of PD than those aged ≥50 years. Future studies are warranted to elucidate the pathomechanism of EOPD in relation to mental illness. © 2024, The Author(s).
- DOI
- 10.1038/s41531-023-00621-x
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML