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Risk of uterine leiomyomata with menstrual and reproductive factors in premenopausal women: Korea nurses’ health study

Title
Risk of uterine leiomyomata with menstrual and reproductive factors in premenopausal women: Korea nurses’ health study
Authors
SongSihanParkSoojinBo MiLeeJung EunChaChiyoungHyun-Young
Ewha Authors
차지영
SCOPUS Author ID
차지영scopus
Issue Date
2023
Journal Title
BMC Women's Health
ISSN
1472-6874JCR Link
Citation
BMC Women's Health vol. 23, no. 1
Keywords
MenarcheMenstrual cyclesProspective studiesReproductive healthUterine leiomyomata
Publisher
BioMed Central Ltd
Indexed
SCIE; SSCI; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: Uterine leiomyomata (UL) are benign smooth muscle tumors that may cause significant morbidity in women of reproductive age. This study aimed to investigate the relationship of menstrual and reproductive factors with the risk of UL in premenopausal women. Methods: This prospective study included 7,360 premenopausal women aged 22–48 years who were part of the Korea Nurses’ Health Study. Information on the menstrual cycle and reproductive history was assessed between 2014 and 2016, and self-reported cases of UL were obtained through 2021. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During 32,072 person-years of follow-up, 447 incident cases of UL were reported. After adjusting for other risk factors, women with late age at menarche had a lower incidence of UL (≥ 16 vs. 12–13 years: HR 0.68; 95% CI 0.47–0.99; p for trend = 0.026). The risk of UL was inversely associated with current menstrual cycle length (≥ 40 or too irregular to estimate vs. 26–31 days: HR 0.40; 95% CI 0.24–0.66) and cycle length at ages 18–22 years (HR 0.45; 95% CI 0.31–0.67; p for trend < 0.001, each). Parous women had lower risk of UL than nulliparous women (HR 0.40; 95% CI 0.30–0.53) and women who were aged 29–30 years at first birth had a lower risk of UL than those who were aged ≤ 28 years at first birth (HR 0.58; 95% CI 0.34–0.98). There was no significant association of the number of births or breastfeeding with the risk of UL among parous women. Neither a history of infertility nor oral contraceptive use was associated with the risk of UL. Conclusions: Our results suggest that age at menarche, menstrual cycle length, parity, and age at first birth are inversely associated with the risk of UL in premenopausal Korean women. Future studies are warranted to confirm the long-term effects of menstrual and reproductive factors on women’s health. © 2023, The Author(s).
DOI
10.1186/s12905-023-02447-4
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간호대학 > 간호학전공 > Journal papers
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