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Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery
- Title
- Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery
- Authors
- Shin, Kyounghee; Lee, Kun Bong; Hwang, Jee-Hyun; Lee, Boryeong; Ryu, Hyunsun; Noh, Minjoo; Lee, Jun Bae; Nam, Yoon Sung; Lim, Kyung-Min; Kim, Jin Woong
- Ewha Authors
- 임경민; 황지현
- SCOPUS Author ID
- 임경민; 황지현
- Issue Date
- 2023
- Journal Title
- JOURNAL OF MATERIALS CHEMISTRY B
- ISSN
- 2050-750X
2050-7518
- Citation
- JOURNAL OF MATERIALS CHEMISTRY B vol. 11, no. 10, pp. 2135 - 2144
- Publisher
- ROYAL SOC CHEMISTRY
- Indexed
- SCOPUS
- Document Type
- Article
- Abstract
- This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone N-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
- DOI
- 10.1039/d2tb02734h
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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