Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임경민 | * |
dc.contributor.author | 황지현 | * |
dc.date.accessioned | 2023-04-14T16:31:12Z | - |
dc.date.available | 2023-04-14T16:31:12Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2050-750X | * |
dc.identifier.issn | 2050-7518 | * |
dc.identifier.other | OAK-33130 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/264879 | - |
dc.description.abstract | This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone N-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2135 | * |
dc.relation.lastpage | 2144 | * |
dc.relation.journaltitle | JOURNAL OF MATERIALS CHEMISTRY B | * |
dc.identifier.doi | 10.1039/d2tb02734h | * |
dc.identifier.wosid | WOS:000933157800001 | * |
dc.identifier.scopusid | 2-s2.0-85148675171 | * |
dc.author.google | Shin, Kyounghee | * |
dc.author.google | Lee, Kun Bong | * |
dc.author.google | Hwang, Jee-Hyun | * |
dc.author.google | Lee, Boryeong | * |
dc.author.google | Ryu, Hyunsun | * |
dc.author.google | Noh, Minjoo | * |
dc.author.google | Lee, Jun Bae | * |
dc.author.google | Nam, Yoon Sung | * |
dc.author.google | Lim, Kyung-Min | * |
dc.author.google | Kim, Jin Woong | * |
dc.contributor.scopusid | 임경민(8916551700) | * |
dc.contributor.scopusid | 황지현(56668147900) | * |
dc.date.modifydate | 20240318113424 | * |