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Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4(+) T-cell responses
- Title
- Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4(+) T-cell responses
- Authors
- Lee, In-Gu; Joo, Yong-Hyun; Jeon, Hoyeon; Jeong, Raehyuk; Kim, Eui Ho; Chung, Hyunwoo; Eyun, Seong-il; Kim, Jeongkyu; Seo, Young-Jin; Hong, So-Hee
- Ewha Authors
- 홍소희
- SCOPUS Author ID
- 홍소희
- Issue Date
- 2023
- Journal Title
- JOURNAL OF LEUKOCYTE BIOLOGY
- ISSN
- 0741-5400
1938-3673
- Citation
- JOURNAL OF LEUKOCYTE BIOLOGY vol. 113, no. 1, pp. 71 - 83
- Keywords
- galectin-4; M1 macrophage; M2 macrophage; CD4(+) T cell; lymphocytic choriomeningitis virus
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Gal-4 enhances the immunostimulatory activity of M2 macrophages upon viral infection, leading to the reinforced antiviral functionality of CD4(+) T cells. Galectin-4 (Gal-4) is a beta-galactoside-binding protein belonging to the galectin family. Although Gal-4 is known to be involved in several physiologic processes of the gastrointestinal tract, its immunomodulatory roles remain unclear. In this study, we investigated whether Gal-4 influences the function of M1 and M2 macrophages. Gal-4 treatment drove more robust changes in the gene expression of M2 macrophages compared to M1 macrophages. Antiviral immune response-related genes were significantly upregulated in Gal-4-treated M2 macrophages. Gal-4 significantly enhanced the immunostimulatory activity of M2 macrophages upon Toll-like receptor 7 stimulation or infection with lymphocytic choriomeningitis virus (LCMV). Moreover, the antibody production against LCMV infection and the antiviral CD4(+) T-cell responses, but not the antiviral CD8(+) T-cell responses, were greatly increased by Gal-4-treated M2 macrophages in vivo. The present results indicate that Gal-4 enhances the ability of M2 macrophages to promote antiviral CD4(+) T-cell responses. Thus, Gal-4 could be used to boost antiviral immune responses.
- DOI
- 10.1093/jleuko/qiac008
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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