Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍소희 | * |
dc.date.accessioned | 2023-04-14T16:31:12Z | - |
dc.date.available | 2023-04-14T16:31:12Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 0741-5400 | * |
dc.identifier.issn | 1938-3673 | * |
dc.identifier.other | OAK-33132 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/264877 | - |
dc.description.abstract | Gal-4 enhances the immunostimulatory activity of M2 macrophages upon viral infection, leading to the reinforced antiviral functionality of CD4(+) T cells. Galectin-4 (Gal-4) is a beta-galactoside-binding protein belonging to the galectin family. Although Gal-4 is known to be involved in several physiologic processes of the gastrointestinal tract, its immunomodulatory roles remain unclear. In this study, we investigated whether Gal-4 influences the function of M1 and M2 macrophages. Gal-4 treatment drove more robust changes in the gene expression of M2 macrophages compared to M1 macrophages. Antiviral immune response-related genes were significantly upregulated in Gal-4-treated M2 macrophages. Gal-4 significantly enhanced the immunostimulatory activity of M2 macrophages upon Toll-like receptor 7 stimulation or infection with lymphocytic choriomeningitis virus (LCMV). Moreover, the antibody production against LCMV infection and the antiviral CD4(+) T-cell responses, but not the antiviral CD8(+) T-cell responses, were greatly increased by Gal-4-treated M2 macrophages in vivo. The present results indicate that Gal-4 enhances the ability of M2 macrophages to promote antiviral CD4(+) T-cell responses. Thus, Gal-4 could be used to boost antiviral immune responses. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.subject | galectin-4 | * |
dc.subject | M1 macrophage | * |
dc.subject | M2 macrophage | * |
dc.subject | CD4(+) T cell | * |
dc.subject | lymphocytic choriomeningitis virus | * |
dc.title | Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4(+) T-cell responses | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 113 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 71 | * |
dc.relation.lastpage | 83 | * |
dc.relation.journaltitle | JOURNAL OF LEUKOCYTE BIOLOGY | * |
dc.identifier.doi | 10.1093/jleuko/qiac008 | * |
dc.identifier.wosid | WOS:000911647700007 | * |
dc.identifier.scopusid | 2-s2.0-85148682575 | * |
dc.author.google | Lee, In-Gu | * |
dc.author.google | Joo, Yong-Hyun | * |
dc.author.google | Jeon, Hoyeon | * |
dc.author.google | Jeong, Raehyuk | * |
dc.author.google | Kim, Eui Ho | * |
dc.author.google | Chung, Hyunwoo | * |
dc.author.google | Eyun, Seong-il | * |
dc.author.google | Kim, Jeongkyu | * |
dc.author.google | Seo, Young-Jin | * |
dc.author.google | Hong, So-Hee | * |
dc.contributor.scopusid | 홍소희(57197470752) | * |
dc.date.modifydate | 20240315135631 | * |