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The association between carbon and nitrogen stable isotope ratios of human hair and hypertension

Title
The association between carbon and nitrogen stable isotope ratios of human hair and hypertension
Authors
AhnSong VogueParkJong-Ku
Ewha Authors
안성복
SCOPUS Author ID
안성복scopus
Issue Date
2023
Journal Title
Clinical Hypertension
ISSN
2056-5909JCR Link
Citation
Clinical Hypertension vol. 29, no. 1
Keywords
Blood pressureCarbonHypertensionIsotopesNitrogen
Publisher
BioMed Central Ltd
Indexed
SCOPUS scopus
Document Type
Article
Abstract
Background: The relationship between stable isotope ratios and dietary protein sources has been reported. However, few studies have examined the effect of stable isotope ratios on metabolic risk in humans. We investigated whether the stable isotope ratios of carbon and nitrogen in human hair are associated with blood pressure and hypertension. Methods: We conducted a cross-sectional study of 392 subjects (228 men and 164 women). Hair samples of the subjects were used for the measurement of stable isotope ratios of carbon (δ13C) and nitrogen (δ15N). Results: The δ13C and δ15N values showed positive correlations with diastolic blood pressure in the subjects without antihypertensive medication. In the subjects without antihypertensive medication, the multivariable-adjusted odds ratio (95% confidence interval) for hypertension was 1.55 (1.04–2.30) per 1‰ increase in δ15N and 1.22 (0.86–1.73) per 1‰ increase in δ13C, respectively. However, in the subjects with antihypertensive medication, neither δ13C nor δ15N values showed a significant association with hypertension. Conclusions: The stable isotopic ratio of nitrogen in scalp hair is independently associated with hypertension in subjects without antihypertensive medication. The hair δ15N value might be used as a surrogate marker to screen a high-risk population for hypertension. © 2023, The Author(s).
DOI
10.1186/s40885-022-00228-z
Appears in Collections:
신산업융합대학 > 융합보건학과 > Journal papers
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