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Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe
- Title
- Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe
- Authors
- Liu, Xiaosheng; Zeng, Shuang; Zhang, Ming; Jiang, Maojun; Kafuti, Yves S.; Shangguan, Pingping; Yu, Yichu; Chen, Qixian; Wang, Jingyun; Peng, Xiaojun; Yoon, Juyoung; Li, Haidong
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
- Issue Date
- 2022
- Journal Title
- CHEMICAL COMMUNICATIONS
- ISSN
- 1359-7345
1364-548X
- Citation
- CHEMICAL COMMUNICATIONS vol. 58, no. 81, pp. 11438 - 11441
- Publisher
- ROYAL SOC CHEMISTRY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.
- DOI
- 10.1039/d2cc04112j
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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