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Resveratrol-β-Lactoglobulin Composite Nanocoating by Layer-by-Layer Assembly with Fe(III)-Tannic Acid Complex

Title
Resveratrol-β-Lactoglobulin Composite Nanocoating by Layer-by-Layer Assembly with Fe(III)-Tannic Acid Complex
Authors
Cho Y.S.Kim S.Kim Y.-K.Jin S.G.Park J.H.
Ewha Authors
박지훈
SCOPUS Author ID
박지훈scopus
Issue Date
2021
Journal Title
Chemistry - An Asian Journal
ISSN
1861-4728JCR Link
Citation
Chemistry - An Asian Journal vol. 16, no. 22, pp. 3636 - 3639
Keywords
NanostructuresResveratrolTannic acidThin filmsβ-Lactoglobulin
Publisher
John Wiley and Sons Ltd
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Resveratrol (3,4’,5-trihydroxystilbene) is beneficial to human health due to its diverse biological activities including its anti-inflammatory and anti-oxidative effects as confirmed by pharmacokinetic tests. Despite these clinical merits, resveratrol's limited hydrosolubility and chemical vulnerability remain challenging with regard to developing a controlled delivery system with enhanced bioavailability. In this work, we report a resveratrol-β-lactoglobulin (R-BLG) composite nanocoating through a layer-by-layer assembly with Fe(III)-tannic acid nanofilms. The R-BLG composite nanocoating can be formed in planar and particulate substrates, showing excellent film stability under a broad range of pH values and against enzymatic digestion during a weeklong incubation. We envision that the proteinaceous nanocoating herein could be combined with existing pharmaceutical carrier materials (e. g., microcapsules and nanoparticles) to realize advanced drug delivery systems with an expanded repertoire of hydrophobic drugs. © 2021 Wiley-VCH GmbH
DOI
10.1002/asia.202100923
Appears in Collections:
사범대학 > 과학교육과 > Journal papers
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