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Extracellular Vesicles from Korean Codium fragile and Sargassum fusiforme Negatively Regulate Melanin Synthesis

Title
Extracellular Vesicles from Korean Codium fragile and Sargassum fusiforme Negatively Regulate Melanin Synthesis
Authors
Jang, BoheeChung, HeesungJung, HyejungSong, Hyun-KukPark, EunhyeChoi, Hack SunJung, KyuhyunChoe, HanYang, SanghwaOh, Eok-Soo
Ewha Authors
오억수정희성장보희
SCOPUS Author ID
오억수scopus; 정희성scopus; 장보희scopus
Issue Date
2021
Journal Title
MOLECULES AND CELLS
ISSN
1016-8478JCR Link

0219-1032JCR Link
Citation
MOLECULES AND CELLS vol. 44, no. 10, pp. 736 - 745
Keywords
extracellular vesiclesmelanin synthesisseaweedskin epidermis
Publisher
KOREAN SOC MOLECULAR &

CELLULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Although various marine ingredients have been exploited for the development of cosmetic products, no previous study has examined the potential of seaweed extracellular vesicles (EV) in such applications. Our results revealed that EV from Codium fragile and Sargassum fusiforme effectively decreased alpha-MSH-mediated melanin synthesis in MNT-1 human melanoma cells, associated with downregulation of MITF (microphthalmia-associated transcription factor), tyrosinase and TRP1 (tyrosinase-related proteins 1). The most effective inhibitory concentrations of EV were 250 mu g/ml for S. fusiforme and 25 mu g/mlfor C. fragile, without affecting the viability of MNT-1 cells. Both EV reduced melanin synthesis in the epidermal basal layer of a three-dimensional model of human epidermis. Moreover, the application of the prototype cream containing C. fragile EV (final 5 mu g/ml) yielded 1.31 % improvement in skin brightness in a clinical trial. Together, these results suggest that EV from C. fragile and S. fusiforme reduce melanin synthesis and may be potential therapeutic and/or supplementary whitening agents.
DOI
10.14348/molcells.2021.2167
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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