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dc.contributor.author오억수-
dc.contributor.author정희성-
dc.contributor.author장보희-
dc.date.accessioned2021-12-01T16:30:58Z-
dc.date.available2021-12-01T16:30:58Z-
dc.date.issued2021-
dc.identifier.issn1016-8478-
dc.identifier.issn0219-1032-
dc.identifier.otherOAK-30544-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/259616-
dc.description.abstractAlthough various marine ingredients have been exploited for the development of cosmetic products, no previous study has examined the potential of seaweed extracellular vesicles (EV) in such applications. Our results revealed that EV from Codium fragile and Sargassum fusiforme effectively decreased alpha-MSH-mediated melanin synthesis in MNT-1 human melanoma cells, associated with downregulation of MITF (microphthalmia-associated transcription factor), tyrosinase and TRP1 (tyrosinase-related proteins 1). The most effective inhibitory concentrations of EV were 250 mu g/ml for S. fusiforme and 25 mu g/mlfor C. fragile, without affecting the viability of MNT-1 cells. Both EV reduced melanin synthesis in the epidermal basal layer of a three-dimensional model of human epidermis. Moreover, the application of the prototype cream containing C. fragile EV (final 5 mu g/ml) yielded 1.31 % improvement in skin brightness in a clinical trial. Together, these results suggest that EV from C. fragile and S. fusiforme reduce melanin synthesis and may be potential therapeutic and/or supplementary whitening agents.-
dc.languageEnglish-
dc.publisherKOREAN SOC MOLECULAR &amp-
dc.publisherCELLULAR BIOLOGY-
dc.subjectextracellular vesicles-
dc.subjectmelanin synthesis-
dc.subjectseaweed-
dc.subjectskin epidermis-
dc.titleExtracellular Vesicles from Korean Codium fragile and Sargassum fusiforme Negatively Regulate Melanin Synthesis-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume44-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage736-
dc.relation.lastpage745-
dc.relation.journaltitleMOLECULES AND CELLS-
dc.identifier.doi10.14348/molcells.2021.2167-
dc.identifier.wosidWOS:000714746800001-
dc.author.googleJang, Bohee-
dc.author.googleChung, Heesung-
dc.author.googleJung, Hyejung-
dc.author.googleSong, Hyun-Kuk-
dc.author.googlePark, Eunhye-
dc.author.googleChoi, Hack Sun-
dc.author.googleJung, Kyuhyun-
dc.author.googleChoe, Han-
dc.author.googleYang, Sanghwa-
dc.author.googleOh, Eok-Soo-
dc.contributor.scopusid오억수(7101967153)-
dc.contributor.scopusid정희성(35106799300)-
dc.contributor.scopusid장보희(55242403100)-
dc.date.modifydate20230210132906-
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자연과학대학 > 생명과학전공 > Journal papers
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