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A "Prime and Deploy" Strategy for Universal Influenza Vaccine Targeting Nucleoprotein Induces Lung-Resident Memory CD8 T cells

Title
A "Prime and Deploy" Strategy for Universal Influenza Vaccine Targeting Nucleoprotein Induces Lung-Resident Memory CD8 T cells
Authors
Chung, HaerynnKim, Eun-AhChang, Jun
Ewha Authors
장준
SCOPUS Author ID
장준scopus
Issue Date
2021
Journal Title
IMMUNE NETWORK
ISSN
1598-2629JCR Link

2092-6685JCR Link
Citation
IMMUNE NETWORK vol. 21, no. 4
Keywords
Lung CD8 T-RMDNA vaccineAdenovirus vectorIntranasalInfluenza B virus
Publisher
KOREA ASSOC IMMUNOLOGISTS
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Lung-resident memory T cells (T-RM) play an essential role in protecting against pulmonary virus infection. Parenteral administration of DNA vaccine is generally not sufficient to induce lung CD8 T-RM cells. This study investigates whether intramuscularly administered DNA vaccine expressing the nucleoprotein (NP) induces lung T-RM cells and protects against the influenza B virus. The results show that DNA vaccination poorly generates lung T-RM cells and massive secondary effector CD8 T cells entering the lungs after challenge infection do not offer sufficient protection. Nonetheless, intranasal administration of non-replicating adenovirus vector expressing no Ag following priming DNA vaccination deploys NP-specific CD8T T-RM cells in the lungs, which subsequently offers complete protection. This novel 'prime and deploy' strategy could be a promising regimen for a universal influenza vaccine targeting the conserved NP Ag.
DOI
10.4110/in.2021.21.e28
Appears in Collections:
약학대학 > 약학과 > Journal papers
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