Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장준 | * |
dc.date.accessioned | 2021-11-10T16:31:04Z | - |
dc.date.available | 2021-11-10T16:31:04Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1598-2629 | * |
dc.identifier.issn | 2092-6685 | * |
dc.identifier.other | OAK-30128 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259315 | - |
dc.description.abstract | Lung-resident memory T cells (T-RM) play an essential role in protecting against pulmonary virus infection. Parenteral administration of DNA vaccine is generally not sufficient to induce lung CD8 T-RM cells. This study investigates whether intramuscularly administered DNA vaccine expressing the nucleoprotein (NP) induces lung T-RM cells and protects against the influenza B virus. The results show that DNA vaccination poorly generates lung T-RM cells and massive secondary effector CD8 T cells entering the lungs after challenge infection do not offer sufficient protection. Nonetheless, intranasal administration of non-replicating adenovirus vector expressing no Ag following priming DNA vaccination deploys NP-specific CD8T T-RM cells in the lungs, which subsequently offers complete protection. This novel 'prime and deploy' strategy could be a promising regimen for a universal influenza vaccine targeting the conserved NP Ag. | * |
dc.language | English | * |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | * |
dc.subject | Lung CD8 T-RM | * |
dc.subject | DNA vaccine | * |
dc.subject | Adenovirus vector | * |
dc.subject | Intranasal | * |
dc.subject | Influenza B virus | * |
dc.title | A "Prime and Deploy" Strategy for Universal Influenza Vaccine Targeting Nucleoprotein Induces Lung-Resident Memory CD8 T cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 21 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.journaltitle | IMMUNE NETWORK | * |
dc.identifier.doi | 10.4110/in.2021.21.e28 | * |
dc.identifier.wosid | WOS:000691603600003 | * |
dc.author.google | Chung, Haerynn | * |
dc.author.google | Kim, Eun-Ah | * |
dc.author.google | Chang, Jun | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.date.modifydate | 20231120165756 | * |