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Effects of cytidine-5 '-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study
- Title
- Effects of cytidine-5 '-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study
- Authors
- Jeong, Hyeonseok; Yoon, Sujung; Sung, Young-Hoon; Kim, Jungyoon; Lyoo, In Kyoon; Yurgelun-Todd, Deborah A.; Renshaw, Perry F.
- Ewha Authors
- 류인균; 윤수정; 김정윤
- SCOPUS Author ID
- 류인균; 윤수정; 김정윤
- Issue Date
- 2021
- Journal Title
- JOURNAL OF PSYCHIATRIC RESEARCH
- ISSN
- 0022-3956
1879-1379
- Citation
- JOURNAL OF PSYCHIATRIC RESEARCH vol. 143, pp. 215 - 221
- Keywords
- Cytidine-5 '-diphosphate choline; Methamphetamine; Magnetic resonance imaging; Gray matter volume
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Indexed
- SCIE; SSCI; SCOPUS
- Document Type
- Article
- Abstract
- Background: Cytidine-5'-diphosphate choline (CDP-choline) has been suggested to exert neuroprotective and neuroreparative effects and may be beneficial for patients with stimulant dependence. This randomized, double-blind, placebo-controlled study in methamphetamine (MA) dependence investigated effects of CDP-choline on the brain structures and their associations with craving and MA use. Methods: MA users (n = 44) were randomized to receive 2 g/day of CDP-choline (n = 22) or placebo (n = 22) for 8 weeks. Patients underwent brain magnetic resonance imaging (MRI) at baseline and 8-week follow-up. Healthy individuals (n = 27) were also examined using brain MRI at the same interval. Voxel-based morphometry analysis was conducted to examine changes in gray matter (GM) volumes and their associations with craving and MA use. Results: Craving for MA was significantly reduced after the 8 week-treatment with CDP-choline (p = 0.01), but not with the placebo treatment (p = 0.10). There was no significant difference in the total number of MA-negative urine samples between the two groups (p = 0.19). With CDP-choline treatment, GM volumes in the left middle frontal gyrus (p = 0.001), right hippocampus (p = 0.009), and left precuneus (p = 0.001) were significantly increased compared to the placebo and control groups. Increased GM volumes in the left middle frontal gyrus with CDP-choline treatment were associated with reduced craving for MA (Spearman's rho = -0.56, p = 0.03). In addition, the right hippocampal volume increases were positively associated with the total number of MA-negative urine results in the CDP-choline group (Spearman's rho = 0.67, p = 0.006). Conclusion: Our findings suggest that CDP-choline may increase GM volumes of MA-dependent patients, which may be related to decreases in MA use and craving.
- DOI
- 10.1016/j.jpsychires.2021.09.006
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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